Klf6 protects β-cells against insulin resistance-induced dedifferentiation

• Main Authors: Christopher Dumayne (Author), David Tarussio (Author), Ana Rodriguez Sanchez-Archidona (Author), Alexandre Picard (Author), Davide Basco (Author), Xavier Pascal Berney (Author), Mark Ibberson (Author), Bernard Thorens (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: In the pathogenesis of type 2 diabetes, development of insulin resistance triggers an increase in pancreatic β-cell insulin secretion capacity and β-cell number. Failure of this compensatory mechanism is caused by a dedifferentiation of β-cells, which leads to insufficient insulin secret...