Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα

• Hauptverfasser: Ilija N. Cvijetić (Verfasst von), Barbara Herlah (Verfasst von), Aleksandar Marinković (Verfasst von), Andrej Perdih (Verfasst von), Snežana K. Bjelogrlić (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2023-02-01T00:00:00Z.
• Schlagworte: article
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Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural simil...