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Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα

Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural simil...

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Bibliographic Details
Main Authors:	Ilija N. Cvijetić (Author), Barbara Herlah (Author), Aleksandar Marinković (Author), Andrej Perdih (Author), Snežana K. Bjelogrlić (Author)
Format:	Book
Published:	MDPI AG, 2023-02-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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