RAGE receptor and its soluble isoforms in diabetes mellitus complications

• Main Authors: Mauren Isfer Anghebem Oliveira (Author), Emanuel Maltempi de Souza (Author), Fábio de Oliveira Pedrosa (Author), Rosângela Roginski Réa (Author), Alexessander da Silva Couto Alves (Author), Geraldo Picheth (Author), Fabiane Gomes de Moraes Rego (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Chronic hyperglycemia, which is present in all types of diabetes, increases the formation of advanced glycation end-products (AGEs). The interaction of AGEs with receptor of advanced glycation end-products (RAGE) initiates a cascade of pro-inflammatory and pro-coagulant processes that result in oxidative stress, stimulating the formation and accumulation of more AGE molecules. This cyclic process, denominated metabolic memory, may explain the persistency of diabetic vascular complications in patients with satisfactory glycemic control. The RAGE found in several cell membranes is also present in soluble isoforms (esRAGE and cRAGE), which are generated by alternative deoxyribonucleic acid splicing or by proteolytic cleavage. This review focuses on new research into these mediators as potential biomarkers for vascular complications in diabetes.

Item Description

1678-4774
10.1590/S1676-24442013000200004