Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling

Abstract Background The aim of this study was to investigate the protective effect and mechanism of oridonin in an in vitro lipopolysaccharide (LPS)-induced human periodontal ligament stem cells (hPDLSCs) model of periodontitis. Methods Primary hPDLSCs were isolated and cultured, and then the expres...

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Main Authors: Junhao Jiang (Author), Nong Zhang (Author), Haibo Song (Author), Ya Yang (Author), Juan Li (Author), Xiaoli Hu (Author)
Format: Book
Published: BMC, 2023-03-01T00:00:00Z.
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