Combined Intravenous Sildenafil and l-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow

• Main Authors: Marek Brzezinski (Author), Gabriela R. Dincheva (Author), Kelsey Alloo (Author), Celeste Wong (Author), Chun-Miao Feng (Author), Wynnis L. Tom (Author), Ali Salahieh (Author), Arthur W. Wallace (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Endothelial dysfunction in the nitric oxide-cyclic guanosine monophosphate pathway is a potential contributor to perioperative myocardial ischemia. The nitric oxide precursor, l-arginine, and the cyclic guanosine monophosphate degradation blocker, sildenafil, have vasodilatory ef...