Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K/AKT signaling

• Main Authors: Xiaoman Yang (Author), Kehua Wang (Author), Jiajia Lang (Author), Danyang Guo (Author), Haixia Gao (Author), Yue Qiu (Author), Xiaohan Jin (Author), Mingyue Zhang (Author), Jiaxiu Shi (Author), QianQian Ma (Author), Qian Ma (Author), Zixi Wen (Author)
• Format: Book
• Published: BMC, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background MicroRNAs are a type of non-coding single-stranded RNA, which is involved in the regulation of ovary insulin resistance (IR). This study aims to explore the underlying mechanisms of miR-133a-3p regulating ovary IR in obese polycystic ovary syndrome (PCOS). Methods Granulosa cells...