Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

• Auteurs principaux: Tongcui Jiang (Auteur), Emily Handley (Auteur), Mariana Brizuela (Auteur), Edgar Dawkins (Auteur), Katherine E. A. Lewis (Auteur), Rosemary M. Clark (Auteur), Tracey C. Dickson (Auteur), Catherine A. Blizzard (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2019-05-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization and aggregation of which are key pathological fea...