Yangonin Blocks Tumor Necrosis Factor-α-Induced Nuclear Factor-κB-Dependent Transcription by Inhibiting the Transactivation Potential of the RelA/p65 Subunit

• Main Authors: Juan Ma (Author), He Liang (Author), Hong Ri Jin (Author), Nguyen Tien Dat (Author), Shan Yu Zhang (Author), Ying Zi Jiang (Author), Ji Xing Nan (Author), Donghao Li (Author), Xue Wu (Author), Jung Joon Lee (Author), Xuejun Jin (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and apoptosis. In our search for NF-κB inhibitors from natural resources, we identified yangonin from Piper methysticum as an inhibitor of NF-κB activation. In the present study...