Coupling Aptamers to Short Interfering RNAs as Therapeutics

• Main Authors: Vittorio de Franciscis (Author), Laura Cerchia (Author), Carla Lucia Esposito (Author), Simona Camorani (Author), Silvia Catuogno (Author)
• Format: Book
• Published: MDPI AG, 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA-based approaches are among the most promising strategies aimed at developing safer and more effective therapeutics. RNA therapeutics include small non-coding miRNAs, small interfering RNA, RNA aptamers and more recently, small activating RNAs. However, major barriers exist to the use of RNAs as...