4',6-Dihydroxy-4-methoxyisoaurone Inhibits the HIF-1α Pathway Through Inhibition of Akt/mTOR/p70S6K/4E-BP1 Phosphorylation

4',6-Dihydroxy-4-methoxyisoaurone Inhibits the HIF-1α Pathway Through Inhibition of Akt/mTOR/p70S6K/4E-BP1 Phosphorylation

Abstract.: 4',6-Dihydroxy-4-methoxyisoaurone (ISOA) is an isoaurone compound isolated from Trichosanthes kirilowii seeds, which was identified as an inhibitor of tumor growth. However, the mechanism by which ISOA inhibits hypoxia-inducible factor-1 (HIF-1)-mediated tumor growth is not fully und...

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Main Authors: Chunliu Mi (Author), Juan Ma (Author), Hui Shi (Author), Jing Li (Author), Fei Wang (Author), Jung Joon Lee (Author), Xuejun Jin (Author)
Format: Book
Published: Elsevier, 2014-01-01T00:00:00Z.
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