Expression of PAFR as Part of a Prosurvival Response to Chemotherapy: A Novel Target for Combination Therapy in Melanoma

• Hoofdauteurs: Ana Claudia Onuchic (Auteur), Camila M. L. Machado (Auteur), Renata F. Saito (Auteur), Francisco J. Rios (Auteur), Sônia Jancar (Auteur), Roger Chammas (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2012-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages. Here, we show that treatment of a human melanoma SKmel37 cell line with cisplatin led to incr...