A population pharmacokinetic‐pharmacodynamic model of YH12852, a highly selective 5‐hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation

Abstract YH12852, a novel, highly selective 5‐hydroxytryptamine 4 (5‐HT4) receptor agonist, is currently under development to treat patients with functional constipation. In this study, we aimed to develop a pharmacokinetic (PK)-pharmacodynamic (PD) model that adequately described the time courses o...

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Main Authors: Siun Kim (Author), Hyun A. Lee (Author), Seong Bok Jang (Author), Howard Lee (Author)
Format: Book
Published: Wiley, 2021-08-01T00:00:00Z.
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