Characteristic roadmap of linker governs the rational design of PROTACs

Characteristic roadmap of linker governs the rational design of PROTACs

Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically degrade proteins responsible for the disease. PROTAC is characterized by its unique heterobifunctional structure, which comprises tw...

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Main Authors: Yawen Dong (Author), Tingting Ma (Author), Ting Xu (Author), Zhangyan Feng (Author), Yonggui Li (Author), Lingling Song (Author), Xiaojun Yao (Author), Charles R. Ashby, Jr (Author), Ge-Fei Hao (Author)
Format: Book
Published: Elsevier, 2024-10-01T00:00:00Z.
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