Prediction of Drug-Drug Interaction Potential of Tegoprazan Using Physiologically Based Pharmacokinetic Modeling and Simulation

• Main Authors: Deok Yong Yoon (Author), SeungHwan Lee (Author), In-Jin Jang (Author), Myeongjoong Kim (Author), Heechan Lee (Author), Seokuee Kim (Author), Bongtae Kim (Author), Geun Seog Song (Author), Su-jin Rhee (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to develop a physiologically based pharmacokinetic (PBPK) model of tegoprazan and to predict the drug-drug interaction (DDI) potential between tegoprazan and cytochrome P450 (CYP) 3A4 perpetrators. The PBPK model of tegoprazan was developed using SimCYP Simulator<sup>®</sup...