Chalcone: A potential scaffold for NLRP3 inflammasome inhibitors

• Main Authors: Pritam Thapa (Author), Sunil P. Upadhyay (Author), Vikas Singh (Author), Varun C. Boinpelly (Author), Jianping Zhou (Author), David K. Johnson (Author), Prajwal Gurung (Author), Eung Seok Lee (Author), Ram Sharma (Author), Mukut Sharma (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overactivated NLRP3 inflammasome has been shown to associate with an increasing number of disease conditions. Activation of the NLRP3 inflammasome results in caspase-1-catalyzed formation of active pro-inflammatory cytokines (IL-1β and IL-18) resulting in pyroptosis. The multi-protein composition of...