The effect of drug loading and multiple administration on the protein corona formation and brain delivery property of PEG-PLA nanoparticles

• Main Authors: Yuyun Tang (Author), Jinchao Gao (Author), Tao Wang (Author), Qian Zhang (Author), Antian Wang (Author), Meng Huang (Author), Renhe Yu (Author), Hongzhuan Chen (Author), Xiaoling Gao (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The presence of protein corona on the surface of nanoparticles modulates their physiological interactions such as cellular association and targeting property. It has been shown that α-mangostin (αM)-loaded poly(ethylene glycol)-poly(l-lactide) (PEG-PLA) nanoparticles (NP-αM) specifically increased l...