Comparative sensitivity of automated (Abbott M2000) and manual plasma HIV-1 RNA PCR assays for the detection of persistent viremia after long-term antiretroviral therapy

• Main Authors: Melissa A. Tosiano (Author), Hanna Mar (Author), Dianna Hoeth (Author), Joseph J. Eron (Author), Rajesh T. Gandhi (Author), Deborah K. McMahon (Author), Ronald J. Bosch (Author), John W. Mellors (Author), Joshua C. Cyktor (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The ability of automated, FDA-cleared plasma HIV-1 RNA assays to detect low-level viremia, compared to manual, highly sensitive research-only methods, is not well-defined. We therefore tested paired plasma samples from people with HIV-1 (PWH) on long-term antiretroviral therapy (ART) wit...