Synthesis, Evaluation of Vasorelaxant Activity, and Molecular Docking of Pyranopyrazole Derivatives as Calcium Channel Blockers

• Main Authors: Saghar Mowlazadeh Haghighi (Author), Mohammad Fathalipour (Author), Maryam Abbasi (Author), Azar Purkhosrow (Author), Somayeh Oftadehgan (Author), Ali Khalafi-Nezhad (Author), Elahe Sattarinezhad (Author)
• Format: Book
• Published: Shiraz University of Medical Sciences, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pyranopyrazole analogs are novel synthetic compounds with many biological activities. In this research,we synthesized six new pyranopyrazole derivatives using a biocompatible catalyst and evaluated their vasorelaxant and calcium channel binding properties in isolated rat thoracic aorta. Male Sprague...