Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents

• Main Authors: Yuanying Fang (Author), Daoyong Hu (Author), Huilan Li (Author), Jianguo Hu (Author), Yanhua Liu (Author), Zhifeng Li (Author), Guoliang Xu (Author), Lanying Chen (Author), Yi Jin (Author), Shilin Yang (Author), Zunhua Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7-8.3 times more potent cytotoxicity (IC50 = 1.2-4.7 and 1.7-4.5 μM, respectively) against five hum...