Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents
A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7-8.3 times more potent cytotoxicity (IC50 = 1.2-4.7 and 1.7-4.5 μM, respectively) against five hum...
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Frontiers Media S.A.,
2019-10-01T00:00:00Z.
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| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yuanying Fang |e author |
| 700 | 1 | 0 | |a Daoyong Hu |e author |
| 700 | 1 | 0 | |a Huilan Li |e author |
| 700 | 1 | 0 | |a Huilan Li |e author |
| 700 | 1 | 0 | |a Jianguo Hu |e author |
| 700 | 1 | 0 | |a Yanhua Liu |e author |
| 700 | 1 | 0 | |a Zhifeng Li |e author |
| 700 | 1 | 0 | |a Guoliang Xu |e author |
| 700 | 1 | 0 | |a Lanying Chen |e author |
| 700 | 1 | 0 | |a Yi Jin |e author |
| 700 | 1 | 0 | |a Shilin Yang |e author |
| 700 | 1 | 0 | |a Zunhua Yang |e author |
| 245 | 0 | 0 | |a Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents |
| 260 | |b Frontiers Media S.A., |c 2019-10-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2019.01208 | ||
| 520 | |a A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7-8.3 times more potent cytotoxicity (IC50 = 1.2-4.7 and 1.7-4.5 μM, respectively) against five human tumor cell lines (SMMC-7721, MCF-7, NCI-H460, A549, and HCT-116) in vitro and lower acute toxicity to mice in vivo than did PSD. Furthermore, compound 6 was observed to show potent tumor growth inhibition against mice H22 hepatocellular cells (49.8% at 20 mg/kg) and induce cell cycle at G1 phase and apoptosis in HCT-116 cells. | ||
| 546 | |a EN | ||
| 690 | |a Pulsatilla saponin D | ||
| 690 | |a synthesis | ||
| 690 | |a antiproliferative activity | ||
| 690 | |a acute toxicity | ||
| 690 | |a apoptosis | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 10 (2019) | |
| 787 | 0 | |n https://www.frontiersin.org/article/10.3389/fphar.2019.01208/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8ac6bb599d7e4f29a1223da51f1b27eb |z Connect to this object online. |