Synthesis, Biological Evaluation, and Mode of Action of Pulsatilla Saponin D Derivatives as Promising Anticancer Agents
A series of ester and amide derivatives of triterpenoid saponin Pulsatilla saponin D (PSD) were designed, synthesized, and evaluated for their antiproliferative activity. Compounds 1 and 6 displayed 1.7-8.3 times more potent cytotoxicity (IC50 = 1.2-4.7 and 1.7-4.5 μM, respectively) against five hum...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2019-10-01T00:00:00Z.
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