An Inducible Nitric Oxide Synthase Dimerization Inhibitor Prevents the Progression of Osteoarthritis

• Main Authors: Shang Xian Bo (Author), Wang Yan Jie (Author), Cai De Chao (Author), Ma Sai (Author), Wang Zhe (Author), Zhu Ya Kun (Author), Guo Hui Hui (Author), Wang Chen (Author), Ma Xiao (Author), Hu Zhong Yao (Author), Yu Hao Ran (Author), Zhang Ji Sen (Author), Cheng Wen Dan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Osteoarthritis (OA) is a degenerative joint disease. Excessive nitric oxide (NO) mediates the chondrocyte inflammatory response, apoptosis, and extracellular matrix (ECM) degradation during the occurrence and development of OA. NO in chondrocytes is mainly produced by inducible nitric oxi...