Application of AP-MALDI Imaging Mass Microscope for the Rapid Mapping of Imipramine, Chloroquine, and Their Metabolites in the Kidney and Brain of Wild-Type Mice

• Main Authors: Ariful Islam (Author), Takumi Sakamoto (Author), Qing Zhai (Author), Md. Muedur Rahman (Author), Md. Al Mamun (Author), Yutaka Takahashi (Author), Tomoaki Kahyo (Author), Mitsutoshi Setou (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mass spectrometry imaging (MSI) is well-known for the non-labeling visualization of analytes, including drugs and their metabolites in biological samples. In this study, we applied three different tools of MSI, desorption electrospray ionization (DESI)-MSI, matrix-assisted laser desorption ionizatio...