The role of renal proximal tubule transport in the regulation of blood pressure

• Main Authors: Shoko Horita (Author), Motonobu Nakamura (Author), Masashi Suzuki (Author), Nobuhiko Satoh (Author), Atsushi Suzuki (Author), Yukio Homma (Author), Masaomi Nangaku (Author)
• Format: Book
• Published: The Korean Society of Nephrology, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause severe proximal renal tubular acidosis accompanied by other extrarenal symptoms. The pro...