PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia

• Main Authors: Julia Macente (Author), Nina Nauwelaerts (Author), Francesca M. Russo (Author), Jan Deprest (Author), Karel Allegaert (Author), Bart Lammens (Author), Rodolfo Hernandes Bonan (Author), Jessica M. Turner (Author), Sailesh Kumar (Author), Andrea Diniz (Author), Frederico S. Martins (Author), Pieter Annaert (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio® and approved for the treatment of pulmonary arterial hypertension. Maternal administration of sildenafil during pregnancy is being evaluated for antenatal treatment of several conditions, inc...