Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes

• Main Authors: Keiichiro Matoba (Author), Kensuke Sekiguchi (Author), Yosuke Nagai (Author), Yusuke Takeda (Author), Hiroshi Takahashi (Author), Tamotsu Yokota (Author), Kazunori Utsunomiya (Author), Rimei Nishimura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a critical regulator in the inception and progression of diabetic nephropathy through a mechanism involving mesangial fibro...