Permeability of Metformin across an In Vitro Blood-Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

• Main Authors: Sejal Sharma (Author), Yong Zhang (Author), Khondker Ayesha Akter (Author), Saeideh Nozohouri (Author), Sabrina Rahman Archie (Author), Dhavalkumar Patel (Author), Heidi Villalba (Author), Thomas Abbruscato (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our lab previously established that metformin, a first-line type two diabetes treatment, activates the Nrf2 pathway and improves post-stroke recovery. Metformin's brain permeability value and potential interaction with blood-brain barrier (BBB) uptake and efflux transporters are currently unkno...