Combinatorial Regimen of Carbamazepine and Imipramine Exhibits Synergism against Grandmal Epilepsy in Rats: Inhibition of Pro-Inflammatory Cytokines and PI3K/Akt/mTOR Signaling Pathway

Epilepsy is a neurodegenerative disorder that causes recurring seizures. Thirty-five percent of patients remain refractory, with a higher prevalence of depression. We investigated the anticonvulsant efficacy of carbamazepine (CBZ; 20 and 50 mg/kg), imipramine (IMI; 10 and 20 mg/kg) alone, and as a l...

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Main Authors: Faheem Hyder Pottoo (Author), Mohammed Salahuddin (Author), Firdos Alam Khan (Author), Marwa Abdullah AL Dhamen (Author), Walaa Jafar Alsaeed (Author), Mohamed S. Gomaa (Author), Chittibabu Vatte (Author), Mohammad N. Alomary (Author)
Format: Book
Published: MDPI AG, 2021-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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