Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression.

• Main Authors: Victoria Wahl-Jensen (Author), Sabine Kurz (Author), Friedericke Feldmann (Author), Lukas K Buehler (Author), Jason Kindrachuk (Author), Victor DeFilippis (Author), Jean da Silva Correia (Author), Klaus Früh (Author), Jens H Kuhn (Author), Dennis R Burton (Author), Heinz Feldmann (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zaire ebolavirus (ZEBOV) infections are associated with high lethality in primates. ZEBOV primarily targets mononuclear phagocytes, which are activated upon infection and secrete mediators believed to trigger initial stages of pathogenesis. The characterization of the responses of target cells to ZE...