Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

• Main Authors: Takaaki Furihata (Author), Satoshi Maekawa (Author), Shingo Takada (Author), Naoya Kakutani (Author), Hideo Nambu (Author), Ryosuke Shirakawa (Author), Takashi Yokota (Author), Shintaro Kinugawa (Author)
• Format: Book
• Published: BMC, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its l...