Brugia malayi gene expression in response to the targeting of the Wolbachia endosymbiont by tetracycline treatment.

• Main Authors: Elodie Ghedin (Author), Tiruneh Hailemariam (Author), Jay V DePasse (Author), Xu Zhang (Author), Yelena Oksov (Author), Thomas R Unnasch (Author), Sara Lustigman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Brugia malayi, like most human filarial parasite species, harbors an endosymbiotic bacterium of the genus Wolbachia. Elimination of the endosymbiont leads to sterilization of the adult female. Previous biochemical and genetic studies have established that communication with its endobacterium is esse...