The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi.

• Главные авторы: Higo Fernando Santos Souza (Автор), Sandra Carla Rocha (Автор), Flávia Silva Damasceno (Автор), Ludmila Nakamura Rapado (Автор), Elisabeth Mieko Furusho Pral (Автор), Claudio Romero Farias Marinho (Автор), Ariel Mariano Silber (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Предметы: article
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Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease that affects 5-6 million people in endemic areas of the Americas. Presently, chemotherapy relies on two compounds that were proposed as trypanocidal drugs four decades ago: nifurtimox and benznidazole. Both drugs are able t...