The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi.

• Main Authors: Higo Fernando Santos Souza (Author), Sandra Carla Rocha (Author), Flávia Silva Damasceno (Author), Ludmila Nakamura Rapado (Author), Elisabeth Mieko Furusho Pral (Author), Claudio Romero Farias Marinho (Author), Ariel Mariano Silber (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease that affects 5-6 million people in endemic areas of the Americas. Presently, chemotherapy relies on two compounds that were proposed as trypanocidal drugs four decades ago: nifurtimox and benznidazole. Both drugs are able t...