Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics

• Main Authors: Ivani Pauli (Author), Celso de O. Rezende Jr (Author), Brian W. Slafer (Author), Marco A. Dessoy (Author), Mariana L. de Souza (Author), Leonardo L. G. Ferreira (Author), Abraham L. M. Adjanohun (Author), Rafaela S. Ferreira (Author), Luma G. Magalhães (Author), Renata Krogh (Author), Simone Michelan-Duarte (Author), Ricardo Vaz Del Pintor (Author), Fernando B. R. da Silva (Author), Fabio C. Cruz (Author), Luiz C. Dias (Author), Adriano D. Andricopulo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite's life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus, inhibition of this validated target may lead to the develo...