Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics
Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite's life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus, inhibition of this validated target may lead to the develo...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2022-01-01T00:00:00Z.
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