Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake

• Main Authors: Seungmin Ham (Author), Saori Mukaida (Author), Masaaki Sato (Author), Peter Keov (Author), Tore Bengtsson (Author), Sebastian Furness (Author), Nicholas D. Holliday (Author), Bronwyn A. Evans (Author), Roger J. Summers (Author), Dana S. Hutchinson (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored whether phosphorylation of the β2‐AR by GRK2 has a role in gl...