Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis

• Main Authors: Giorgiana Negrea (Author), Valentin-Florian Rauca (Author), Marta Szilvia Meszaros (Author), Laura Patras (Author), Lavinia Luput (Author), Emilia Licarete (Author), Vlad-Alexandru Toma (Author), Alina Porfire (Author), Dana Muntean (Author), Alina Sesarman (Author), Manuela Banciu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primary melanoma aggressiveness is determined by rapid selection and growth of cellular clones resistant to conventional treatments, resulting in metastasis and recurrence. In addition, a reprogrammed tumor-immune microenvironment supports melanoma progression and response to therapy. There is an ur...