Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen

• Main Authors: Philippe Hermand (Author), Annick Vandercammen (Author), Emmanuel Mertens (Author), Emmanuel Di Paolo (Author), Vincent Verlant (Author), Philippe Denoël (Author), Fabrice Godfroid (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of protein antigens able to protect against the majority of Streptococcus pneumoniae serotypes is envisaged as stand-alone and/or complement to the current capsular polysaccharide-based pneumococcal vaccines. Pneumolysin (Ply) is a key virulence factor that is highly conserved in amino acid...