Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.

• Main Authors: Manuel Modolell (Author), Beak-San Choi (Author), Robert O Ryan (Author), Maggie Hancock (Author), Richard G Titus (Author), Tamrat Abebe (Author), Asrat Hailu (Author), Ingrid Müller (Author), Matthew E Rogers (Author), Charles R M Bangham (Author), Markus Munder (Author), Pascale Kropf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing. Here we show that high arginase activity, a hallmark of nonhealing disease, is p...