Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.

• मुख्य लेखकों: Manuel Modolell (लेखक), Beak-San Choi (लेखक), Robert O Ryan (लेखक), Maggie Hancock (लेखक), Richard G Titus (लेखक), Tamrat Abebe (लेखक), Asrat Hailu (लेखक), Ingrid Müller (लेखक), Matthew E Rogers (लेखक), Charles R M Bangham (लेखक), Markus Munder (लेखक), Pascale Kropf (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing. Here we show that high arginase activity, a hallmark of nonhealing disease, is p...