Local suppression of T cell responses by arginase-induced L-arginine depletion in nonhealing leishmaniasis.
The balance between T helper (Th) 1 and Th2 cell responses is a major determinant of the outcome of experimental leishmaniasis, but polarized Th1 or Th2 responses are not sufficient to account for healing or nonhealing. Here we show that high arginase activity, a hallmark of nonhealing disease, is p...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Public Library of Science (PLoS),
2009-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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