Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

• Main Authors: Mengyao Li (Author), Mohammad A. K. Azad (Author), Maizbha U. Ahmed (Author), Yan Zhu (Author), Jiangning Song (Author), Fanfan Zhou (Author), Hak-Kim Chan (Author), Tony Velkov (Author), Qi Tony Zhou (Author), Jian Li (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in human lung epithelial cells. In the present stu...