Zonisamide Attenuates MPTP Neurotoxicity in Marmosets
Abstract.: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces parkinsonism in humans and animals. The effects of zonisamide on dopamine neurons were studied in MPTP-treated common marmosets (Callithrix jacchus). Groups of animals (n = 3) were treated with MPTP (2.5 mg/kg, every 24 h × 3); M...
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2010-01-01T00:00:00Z.
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| 001 | doaj_8b1e6aa6c9984e6e82daa3f22cfcdfa3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Mohammed Emamussalehin Choudhury |e author |
| 700 | 1 | 0 | |a Takashi Moritoyo |e author |
| 700 | 1 | 0 | |a Hayato Yabe |e author |
| 700 | 1 | 0 | |a Noriko Nishikawa |e author |
| 700 | 1 | 0 | |a Masahiro Nagai |e author |
| 700 | 1 | 0 | |a Madoka Kubo |e author |
| 700 | 1 | 0 | |a Seiji Matsuda |e author |
| 700 | 1 | 0 | |a Masahiro Nomoto |e author |
| 245 | 0 | 0 | |a Zonisamide Attenuates MPTP Neurotoxicity in Marmosets |
| 260 | |b Elsevier, |c 2010-01-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1254/jphs.10120FP | ||
| 520 | |a Abstract.: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces parkinsonism in humans and animals. The effects of zonisamide on dopamine neurons were studied in MPTP-treated common marmosets (Callithrix jacchus). Groups of animals (n = 3) were treated with MPTP (2.5 mg/kg, every 24 h × 3); MPTP plus zonisamide (40 mg/kg administered 1 h before each MPTP dose); MPTP plus selegiline (a known MAO-B inhibitor) (2 mg/kg administered 1 h before each MPTP dose); and saline controls. An immunohistochemical study of the substantia nigra was performed 14 days after MPTP treatment in each group. MPTP reduced the mean number of tyrosine hydroxylase (TH)-positive neurons to 10% of the normal control group and mean cell size was significantly (P < 0.001) reduced from 424 to 159 μm2. In the group pre-treated with zonis amide, the mean number of TH-positive neurons was reduced to 26% of that in the normal control group and the mean neuron size was significantly (P < 0.05) increased from 159 to 273 μm2 compared with the group treated with MPTP alone. Moreover, in the group pre-treated with selegiline, the mean number of TH-positive neurons was 47% of that in the normal control group and the mean neuron size was increased significantly (P < 0.01) from159 to 319 μm2 compared to the group treated with MPTP alone. This observation suggests that zonisamide reduces MPTP toxicity. Keywords:: MPTP, tyrosine hydroxylase (TH)-positive dopaminergic neuron, selegiline, zonisamide, marmoset | ||
| 546 | |a EN | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 114, Iss 3, Pp 298-303 (2010) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861319308412 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/8b1e6aa6c9984e6e82daa3f22cfcdfa3 |z Connect to this object online. |