Zonisamide Attenuates MPTP Neurotoxicity in Marmosets

• Main Authors: Mohammed Emamussalehin Choudhury (Author), Takashi Moritoyo (Author), Hayato Yabe (Author), Noriko Nishikawa (Author), Masahiro Nagai (Author), Madoka Kubo (Author), Seiji Matsuda (Author), Masahiro Nomoto (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induces parkinsonism in humans and animals. The effects of zonisamide on dopamine neurons were studied in MPTP-treated common marmosets (Callithrix jacchus). Groups of animals (n = 3) were treated with MPTP (2.5 mg/kg, every 24 h × 3); M...