High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

• Main Authors: Arvind Pradip (Author), Daniella Steel (Author), Susanna Jacobsson (Author), Gustav Holmgren (Author), Magnus Ingelman-Sundberg (Author), Peter Sartipy (Author), Petter Björquist (Author), Inger Johansson (Author), Josefina Edsbagge (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure...