Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion

• Main Authors: Sandeep Kumar Reddy Adena (Author), Michele Herneisey (Author), Eric Pierce (Author), Paul R. Hartmeier (Author), Suneera Adlakha (Author), Marco A. I. Hosfeld (Author), James K. Drennen (Author), Jelena M. Janjic (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the presented study, we report development of a stable, scalable, and high-quality curcumin-loaded oil/water (o/w) nanoemulsion manufactured by concentration-mediated catastrophic phase inversion as a low energy nanoemulsification strategy. A design of experiments (DoE) was constructed to determi...