Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

• Main Authors: Anne Marit de Groot (Author), Kaushik Thanki (Author), Monique Gangloff (Author), Emily Falkenberg (Author), Xianghui Zeng (Author), Djai C.J. van Bijnen (Author), Willem van Eden (Author), Henrik Franzyk (Author), Hanne M. Nielsen (Author), Femke Broere (Author), Nick J. Gay (Author), Camilla Foged (Author), Alice J.A.M. Sijts (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral nanoparticulate delivery approaches are explored. Recently, we showed tha...