Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway

• Main Authors: Hulinyue Peng (Author), Longtai You (Author), Chunjing Yang (Author), Kaixin Wang (Author), Manting Liu (Author), Dongge Yin (Author), Yuchen Xu (Author), Xiaoxv Dong (Author), Xingbin Yin (Author), Jian Ni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP) is the major bioactive compound extracted from Tripterygium wilfordii Hook F. It exerts anti-inflammatory, antirheumatic, antineoplastic, and neuroprotective effects. However, the severe hepatotoxicity induced by TP limits its clinical application. Ginsenoside Rb1 has been reported t...