Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation

• Main Authors: Caroline Lindblad (Author), Susanne Neumann (Author), Sólrún Kolbeinsdóttir (Author), Vasilios Zachariadis (Author), Eric P. Thelin (Author), Martin Enge (Author), Sebastian Thams (Author), Lou Brundin (Author), Mikael Svensson (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling is one subset. This inflammatory response is heterogeneous with respect to the inductive stimuli and the afflicted central nervous system region. This is of...