Votucalis, a Novel Centrally Sparing Histamine-Binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice

• Main Authors: Ibrahim Alrashdi (Author), Amal Alsubaiyel (Author), Michele Chan (Author), Emma E. Battell (Author), Abdel Ennaceur (Author), Miles A. Nunn (Author), Wayne Weston-Davies (Author), Paul L. Chazot (Author), Ilona Obara (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Votucalis is a biologically active protein in tick (R. appendiculatus) saliva, which specifically binds histamine with high affinity and, therefore, has the potential to inhibit the host's immunological responses at the feeding site. We hypothesized that scavenging of peripherally released endo...