The C-Terminal Region of Serotonin Transporter Is Important for Its Trafficking and Glycosylation

• Main Authors: Mariko Nobukuni (Author), Hideki Mochizuki (Author), Satoshi Okada (Author), Nobuhisa Kameyama (Author), Anna Tanaka (Author), Hikaru Yamamoto (Author), Taku Amano (Author), Takahiro Seki (Author), Norio Sakai (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of brefeldin A and ilimaquinone, inhibitors of membrane trafficking, using serotonin transporter (SERT)-expressing COS-7 cells. Both drugs significantly inhibited the serotonin uptake activity of SERT and caused SERT to be retained in the endoplasmic reticulum (ER), indic...